[Isl] ISL Brown Bag Series, Leo Liu: “Clotting with the Flow: Can we Bioengineer Solutions for Heart Attacks and Strokes?”

[Victoria Simon]

You are invited to hear Faculty Affiliate Leo Liu, Ph.D., speak on “Clotting with the Flow: Can we Bioengineer Solutions for Heart Attacks and Strokes?” at the next Institute for Successful Longevity Brown Bag Talk on October 2, at noon.

You can watch his presentation via Zoom at https://fsu.zoom.us/j/93088181053

Assistant Professor of Chemical and Biomedical Engineering at the FAMU-FSU College of Engineering, Dr. Liu will take questions from the audience after his talk.

Dr. Liu tells us that myocardial infarction (MI) and strokes remain the leading causes of death in the modern world. This can stem from a clot forming in a narrowed artery and obstructing blood flow – a process called occlusive high-shear thrombosis. Current anti-thrombotic therapies, such as Aspirin for example, which target the blood biochemistry, remain largely ineffective while also leading to excessive bleeding risks.

Being able to understand how acute MI and strokes lead to ischemia or fatality (~25%) and eventually developing novel preventive drugs plays a significant role in successful longevity. Recent studies have shown definitive results suggesting high-shear thrombosis is primarily controlled by a biophysical aggregation of cells and proteins mediated by high-shear flows, in contrast to stasis required for “textbook” blood clotting.

In his seminar, Dr. Liu will present how they drive multi-resolution understanding of this flow-mediated clotting process at concurrent molecular, cellular and continuum scales using multiscale computational modeling (in silico) combined with thrombosis-on-a-chip devices. He will also discuss how novel treatment can be inspired and developed from the unconventional biophysics predicted by their in silico and in vitro models, and how their in vitro models could be utilized for drug screening and potentially point-of-care diagnostics with minimal amount of blood draw.


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