[Isl] You're Invited!

[Victoria Simon]

Hello and good afternoon,

We would like to formally invite you to attend a talk by Dr. Abbi Hernandez on Tuesday, January 17th.  Please see the details of the talk below:

Dr. Abbi Hernandez will be giving her job talk for our Neuroscience Learning and Memory search on:


  *   Tuesday, January 17th @ 3:30pm in PDB A211.

See below for Dr. Hernandez' talk title, significance statement, and abstract.

Title:  The gut microbiome as a therapeutic target for cognitive aging and Alzheimer's disease.

Significance Statement:  While nearly 6 million Americans are currently living with the debilitating effects of Alzheimer's disease, the lack of treatment options and impoverished understanding of the underlying causes of cognitive decline, metabolic impairment, impaired gut function and other symptoms leads to severe impairments in quality of life.  This work will help to determine whether alterations in gut microbiome composition influence cognitive outcomes in aging and Alzheimer's disease, and the degree to which this is mediated by alterations in metabolic functioning. Findings from this line of work may reveal specific peripheral targets that can be leveraged for the generation of potential therapeutic strategies against Alzheimer's disease and related symptoms.

Abstract:  Although the human lifespan has significantly increased thanks to modern medicine and technology, there has unfortunately not been a matching increase in healthspan. Age-associated impairments in cognitive and physical health can significantly decrease quality of life. Additionally, Alzheimer's disease (AD) is increasingly prevalent later in life and is now the most common cause of dementia and the third leading cause of death in older adults. In addition to cognitive impairment, AD is associated with neuropathology, impaired metabolic function and gut microbiome dysbiosis. However, the relationships between gut health (including the gut microbiome), metabolism and cognitive decline remains largely unknown, despite strong evidence that the gut-brain-axis is an important intermediary in neurodegenerative disease. Therefore, my work focuses on the mechanisms supporting the bidirectional relationship between peripheral health and function with neurobiological and cognitive outcomes. This work demonstrates the potential for dietary manipulations to significantly shift the composition of the gut microbiome, which then influences neurobiological function in a myriad of ways. By elucidating some of the ways through which peripherally-targeting interventions exert their influence over cognitive function, we may be able to develop mimetics for preventing age-related cognitive decline. Utilizing the gut as a target may provide novel ways to improve the cognitive healthspan that are feasible and well-tolerated relative to traditional pharmacological interventions directly targeting the brain itself.

Hope to see you at the talk!


Victoria Simon
Institute for Successful Longevity
www.isl.fsu.edu
Room 227
Claude-Pepper Building
Florida State University
Tallahassee, FL 32304
850-644-8571
vs22z at fsu.edu<mailto:vs22z at fsu.edu>

Please Note:
Due to Florida's very broad public records law, most written business communications to or from FSU staff and/or any public college or university employee are public records, available to the public and media upon request. Therefore, this e-mail communication may be subject to public disclosure.



-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://lists.fsu.edu/pipermail/isl/attachments/20230103/a97e7a06/attachment.html>