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<p class="MsoNormal"><span lang="EN-CA" style="font-size:12.0pt">Hello and good afternoon,
<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-CA" style="font-size:12.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-CA" style="font-size:12.0pt">We would like to formally invite you to attend a talk by Dr. Abbi Hernandez on Tuesday, January 17<sup>th</sup>. Please see the details of the talk below:<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-CA" style="font-size:12.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span lang="EN-CA" style="font-size:12.0pt">Dr. Abbi Hernandez</span></b><span lang="EN-CA" style="font-size:12.0pt"> will be giving her job talk for our Neuroscience Learning and Memory search on:<o:p></o:p></span></p>
<p class="MsoNormal"><b><span lang="EN-CA" style="font-size:12.0pt;background:yellow;mso-highlight:yellow"><o:p> </o:p></span></b></p>
<ul style="margin-top:0in" type="disc">
<li class="MsoListParagraph" style="margin-left:0in;mso-list:l0 level1 lfo1"><b><span lang="EN-CA" style="font-size:12.0pt;background:yellow;mso-highlight:yellow">Tuesday, January 17<sup>th</sup> @ 3:30pm in PDB A211</span></b><span lang="EN-CA" style="font-size:12.0pt">.
<o:p></o:p></span></li></ul>
<p class="MsoNormal"><span lang="EN-CA" style="font-size:12.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-CA" style="font-size:12.0pt">See below for Dr. Hernandez’ talk title, significance statement, and abstract.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-CA" style="font-size:12.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:12.0pt">Title</span></b><span style="font-size:12.0pt">: <span style="color:black">The gut microbiome as a therapeutic target for cognitive aging and Alzheimer’s disease.</span><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:12.0pt">Significance Statement</span></b><span style="font-size:12.0pt">:
</span><span lang="EN-CA" style="font-size:12.0pt;color:black;background:white">While nearly 6 million Americans are currently living with the debilitating effects of Alzheimer’s disease, the lack of treatment options and impoverished understanding of the underlying
causes of cognitive decline, metabolic impairment, impaired gut function and other symptoms leads to severe impairments in quality of life. This work will help to determine whether alterations in gut microbiome composition influence cognitive outcomes in
aging and Alzheimer’s disease, and the degree to which this is mediated by alterations in metabolic functioning. Findings from this line of work may reveal specific peripheral targets that can be leveraged for the generation of potential therapeutic strategies
against Alzheimer’s disease and related symptoms.</span><span lang="EN-CA" style="font-size:12.0pt;background:white"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:12.0pt">Abstract</span></b><span style="font-size:12.0pt">: Although the human lifespan has significantly increased thanks to modern medicine and technology, there has unfortunately not been a matching increase
in healthspan. Age-associated impairments in cognitive and physical health can significantly decrease quality of life. Additionally, Alzheimer’s disease (AD) is increasingly prevalent later in life and is now the most common cause of dementia and the third
leading cause of death in older adults. In addition to cognitive impairment, AD is associated with neuropathology, impaired metabolic function and gut microbiome dysbiosis. However, the relationships between gut health (including the gut microbiome), metabolism
and cognitive decline remains largely unknown, despite strong evidence that the gut-brain-axis is an important intermediary in neurodegenerative disease. Therefore, my work focuses on the mechanisms supporting the bidirectional relationship between peripheral
health and function with neurobiological and cognitive outcomes. This work demonstrates the potential for dietary manipulations to significantly shift the composition of the gut microbiome, which then influences neurobiological function in a myriad of ways.
By elucidating some of the ways through which peripherally-targeting interventions exert their influence over cognitive function, we may be able to develop mimetics for preventing age-related cognitive decline. Utilizing the gut as a target may provide novel
ways to improve the cognitive healthspan that are feasible and well-tolerated relative to traditional pharmacological interventions directly targeting the brain itself.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-CA" style="font-size:12.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-CA" style="font-size:12.0pt">Hope to see you at the talk!<o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Victoria Simon<o:p></o:p></p>
<p class="MsoNormal">Institute for Successful Longevity<o:p></o:p></p>
<p class="MsoNormal">www.isl.fsu.edu<o:p></o:p></p>
<p class="MsoNormal">Room 227<o:p></o:p></p>
<p class="MsoNormal">Claude-Pepper Building<o:p></o:p></p>
<p class="MsoNormal">Florida State University<o:p></o:p></p>
<p class="MsoNormal">Tallahassee, FL 32304<o:p></o:p></p>
<p class="MsoNormal">850-644-8571<o:p></o:p></p>
<p class="MsoNormal"><a href="mailto:vs22z@fsu.edu">vs22z@fsu.edu</a><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal" style="margin-bottom:12.0pt;background:white"><span style="font-family:"Arial",sans-serif;color:black">Please Note:</span><o:p></o:p></p>
<p class="MsoNormal" style="background:white"><span style="font-family:"Arial",sans-serif;color:black">Due to Florida’s very broad public records law, most written business communications to or from FSU staff and/or any public college or university employee
are public records, available to the public and media upon request. Therefore, this e-mail communication may be subject to public disclosure.</span><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
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