[Isl] Vote for Nate Richbourg as New ISL Faculty Affiliate

[Institute for Successful Longevity]

Dear ISL Affiliates,



I hope this email finds you well.



Dr. Nate Richbourg would like to be considered for ISL Faculty Affiliation.



I have attached his CV and below is his research statement for you to review and then cast your vote.


Nathan Richbourg started as an assistant professor of biomedical engineering in the Chemical and Biomedical Engineering Department at the FAMU-FSU College of Engineering in Fall 2025. He received his PhD in biomedical engineering from the University of Texas at Austin in 2022 with Professor Nicholas Peppas before studying breast cancer dormancy as a postdoctoral researcher in the Peyton lab at UMass and Tufts University. His research interests focus on treating disease through controlled cell-environment interactions. The Richbourg lab coordinates fundamental and modular hydrogel design concepts to create tissue-mimicking materials for 3D cell culture. During his PhD, Dr. Richbourg introduced the Swollen Polymer Network Model of structure-based hydrogel design, which has reached an international audience through his website, hydrogeldesign.org.  These biomaterials mimic how diseases such as cancer, aging, and genetic disorders disrupt healthy processes at the tissue scale. He is especially interested in bone marrow, where maintaining adult hematopoietic stem cells and treating cancer metastasis are critical medical problems.


Aging plays a key role in the marrow microenvironment, as the accumulation of senescent cells and the depletion and increasing myeloid bias of adult hematopoietic stem cells with age fundamentally shifts the local signaling milieu and affects downstream immune function. The age-associated changes to cell characteristics further induce changes to the extracellular matrix composition, which in turn augments the mechanical signals to cells as well as solute transport restriction between cells. This complex interplay of aging, cells, and extracellular matrix requires 3D, tissue-mimicking model systems to evaluate the interacting mechanisms that accelerate age-associated dysfunction. Our modular, cell-encapsulating hydrogels enable this investigation with precise control of biochemical and physical properties. Overall, this tissue-scale analysis will support new approaches for treating degenerative diseases. Specifically, by targeting the bone marrow microenvironment, we will disrupt senescence-associated cell-environment feedforward loops and improve healthspans for aging individuals.


We will keep voting open for two weeks (till October 1st, 2025).



Please cast your vote using the link below.

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