BEGIN:VCALENDAR METHOD:REQUEST PRODID:Microsoft Exchange Server 2010 VERSION:2.0 BEGIN:VTIMEZONE TZID:Eastern Standard Time BEGIN:STANDARD DTSTART:16010101T020000 TZOFFSETFROM:-0400 TZOFFSETTO:-0500 RRULE:FREQ=YEARLY;INTERVAL=1;BYDAY=1SU;BYMONTH=11 END:STANDARD BEGIN:DAYLIGHT DTSTART:16010101T020000 TZOFFSETFROM:-0500 TZOFFSETTO:-0400 RRULE:FREQ=YEARLY;INTERVAL=1;BYDAY=2SU;BYMONTH=3 END:DAYLIGHT END:VTIMEZONE BEGIN:VEVENT ORGANIZER;CN=Zhe He:mailto:Zhe.He@cci.fsu.edu ATTENDEE;ROLE=REQ-PARTICIPANT;PARTSTAT=NEEDS-ACTION;RSVP=TRUE;CN=Yan Li:mai lto:yli@eng.famu.fsu.edu ATTENDEE;ROLE=REQ-PARTICIPANT;PARTSTAT=NEEDS-ACTION;RSVP=TRUE;CN=ISL Affili ates:mailto:isl@lists.fsu.edu DESCRIPTION;LANGUAGE=en-US:\nDear all\,\n\nYou are invited to attend the IS L Brown Bag Talk by Dr. Yan Li from FAMU-FSU College of Engineering on Sep tember 30\, 2026 at 12 PM noon.\n\nTitle:"How Brain Immune Cells Communica te to Protect Against Neurodegeneration”\n\nSpeaker: Dr. Yan Li\n\nDate: Wednesday\, September 30\, 2026\n\nTime: 12:00 PM - 1:00 PM\n\nLocation: Innovation Hub\, Room 126 or Zoom (https://fs u.zoom.us/meeting/register/CYw3I5SfTyi4eH5TJ1NDTg#/registration). In-person participation is encouraged. We will prov ide light refreshments.\n\nWhat is this talk about?\n\nMicroglia are the b rain’s resident immune cells and play an important role in maintaining b rain health. They are also increasingly implicated in Alzheimer’s diseas e\, but how they communicate with other brain cells and influence neurodeg eneration remains poorly understood.\n\nIn this study\, we use human stem- cell-derived brain organoids (“mini-brain” models) to investigate inte ractions between microglia and neural cells in Alzheimer’s disease. We f ocus on extracellular vesicles\, tiny particles released by cells that car ry molecular signals to other cells. Using brain organoids and microglia d erived from healthy individuals and people with genetic risk factors for A lzheimer’s disease\, we examine how these vesicles affect inflammation\, metabolism\, and neural degeneration.\n\nOur findings suggest that extrac ellular vesicles from healthy microglia and microglia-containing brain org anoids can regulate pathways related to inflammation\, Alzheimer’s patho logy\, and cellular metabolism\, offering new insights into brain immune-c ell communication and potential approaches to neuroprotection.\n\nSpeaker Bio\n\nDr. Yan Li is the Simon Ostrach Professor of Engineering and Profes sor of Chemical and Biomedical Engineering at the FAMU-FSU College of Engi neering. Her research focuses on stem cell engineering\, tissue engineerin g\, biomaterials\, and bioprocessing\, with particular interests in human pluripotent stem cells\, brain organoids\, and extracellular vesicles. Her recent work explores how these technologies can be used to better underst and and develop potential treatments for neurological conditions\, includi ng Alzheimer’s disease and stroke. Dr. Li is a Fellow of the American In stitute for Medical and Biological Engineering (AIMBE) and a recipient of the NSF CAREER Award.\n\n UID:040000008200E00074C5B7101A82E0080000000022B870194A15DD01000000000000000 010000000485E8749D080304FB538284BAD2A3BF7 SUMMARY;LANGUAGE=en-US:ISL Brown Bag by Dr. Yan Li DTSTART;TZID=Eastern Standard Time:20260930T120000 DTEND;TZID=Eastern Standard Time:20260930T130000 CLASS:PUBLIC PRIORITY:5 DTSTAMP:20260825T163150Z TRANSP:OPAQUE STATUS:CONFIRMED SEQUENCE:1 LOCATION;LANGUAGE=en-US:Innovation Hub Room 126 or Zoom X-MICROSOFT-CDO-APPT-SEQUENCE:1 X-MICROSOFT-CDO-OWNERAPPTID:2124906644 X-MICROSOFT-CDO-BUSYSTATUS:TENTATIVE X-MICROSOFT-CDO-INTENDEDSTATUS:BUSY X-MICROSOFT-CDO-ALLDAYEVENT:FALSE X-MICROSOFT-CDO-IMPORTANCE:1 X-MICROSOFT-CDO-INSTTYPE:0 X-MICROSOFT-ONLINEMEETINGEXTERNALLINK: X-MICROSOFT-ONLINEMEETINGCONFLINK: X-MICROSOFT-DONOTFORWARDMEETING:FALSE X-MICROSOFT-DISALLOW-COUNTER:FALSE X-MICROSOFT-REQUESTEDATTENDANCEMODE:DEFAULT X-MICROSOFT-ISRESPONSEREQUESTED:TRUE X-MICROSOFT-LOCATIONDISPLAYNAME:Innovation Hub Room 126 or Zoom X-MICROSOFT-LOCATIONSOURCE:None X-MICROSOFT-LOCATIONS:[{"DisplayName":"Innovation Hub Room 126 or Zoom"\,"L ocationAnnotation":""\,"LocationUri":""\,"LocationStreet":""\,"LocationCit y":""\,"LocationState":""\,"LocationCountry":""\,"LocationPostalCode":""\, "LocationFullAddress":""}] BEGIN:VALARM DESCRIPTION:REMINDER TRIGGER;RELATED=START:-PT15M ACTION:DISPLAY END:VALARM END:VEVENT END:VCALENDAR