BEGIN:VCALENDAR METHOD:REQUEST PRODID:Microsoft Exchange Server 2010 VERSION:2.0 BEGIN:VTIMEZONE TZID:Eastern Standard Time BEGIN:STANDARD DTSTART:16010101T020000 TZOFFSETFROM:-0400 TZOFFSETTO:-0500 RRULE:FREQ=YEARLY;INTERVAL=1;BYDAY=1SU;BYMONTH=11 END:STANDARD BEGIN:DAYLIGHT DTSTART:16010101T020000 TZOFFSETFROM:-0500 TZOFFSETTO:-0400 RRULE:FREQ=YEARLY;INTERVAL=1;BYDAY=2SU;BYMONTH=3 END:DAYLIGHT END:VTIMEZONE BEGIN:VEVENT ORGANIZER;CN=Michael McDonald:mailto:michael.mcdonald@fsu.edu DESCRIPTION;LANGUAGE=en-US:"Multimodal Graph Representation Learning for Si ngle-Cell Cancer Genomics"\n\nXian F. Mallory\nDepartment of Computer Scie nce\nFlorida State University (FSU)\n\nPlease feel free to forward/share t his invitation with other groups/disciplines that might be interested in t his talk/topic. All are welcome to attend.\n\nNOTE: In-person attendance i s requested in our 499 Dirac Science Library (DSL) Seminar Room. Zoom acce ss is intended for external (non-departmental) participants only.\n\nhttps ://fsu.zoom.us/j/94273595552\nMeeting # 942 7359 5552\n\n\nWednesday\, Oct 7\, 2026\, Schedule:\n\n *\n3:00 to 3:30 PM Eastern Time (US and Canada) \n *\nā˜• Nespresso & Teatime - 417 DSL Commons\n\n *\n3:30 to 4:30 P M Eastern Time (US and Canada)\n *\nšŸ•Ÿ Colloquium - 499 DSL Seminar Room\n\nAbstract:\nSingle-cell sequencing makes it possible to characteriz e tumor heterogeneity at cellular resolution. However\, each molecular mod ality has inherent limitations. Transcriptomic profiles of malignant and n ormal cells often overlap\, copy number alteration (CNA) signals are low r esolution and not comprehensive\, and single-nucleotide variations (SNVs) are largely unobserved in low-coverage sequencing. This talk presents a gr aph-based framework for integrating complementary modalities. Cells are re presented as nodes\, one modality defines the node features\, and a second modality defines the edge weights. A graph attention autoencoder then lea rns low-dimensional cell embeddings that jointly reflect both sources of i nformation. Two applications of this framework will be discussed. SCGclust performs subclone clustering on ultra-shallow single-cell DNA sequencing data by combining read-count-based CNA features with SNV-derived cell simi larity. It consistently outperforms methods that rely on a single signal. DeepMalignant identifies malignant cells in single-cell RNA sequencing dat a by combining expression signatures with CNA-derived cell similarity. Acr oss 26 samples\, four cancer types\, and three sequencing platforms\, it a chieves the most favorable balance of precision and recall\, and it genera lizes to spatial transcriptomics. Ablation analyses confirm that both the multimodal edge construction and the attention mechanism contribute to per formance.\n\n\nAdditional colloquium details can be found here:\nhttps://w ww.sc.fsu.edu/news-and-events/colloquium/colloquium-with-xian-mallory-2026 -10-07\n\nšŸŽ¦ Co lloquium recordings will be made available here:\nhttps://www.sc.fsu.edu/n ews-and-events/seminars\n UID:040000008200E00074C5B7101A82E008000000004788F91E5756DD01000000000000000 010000000B9A962E141F2F640B99A16CE9F1F4688 SUMMARY;LANGUAGE=en-US:Scientific Computing Colloquium with Xian Mallory DTSTART;TZID=Eastern Standard Time:20261007T153000 DTEND;TZID=Eastern Standard Time:20261007T162500 CLASS:PUBLIC PRIORITY:5 DTSTAMP:20261007T122648Z TRANSP:OPAQUE STATUS:CONFIRMED SEQUENCE:1 LOCATION;LANGUAGE=en-US:https://fsu.zoom.us/j/94273595552 X-MICROSOFT-CDO-APPT-SEQUENCE:1 X-MICROSOFT-CDO-OWNERAPPTID:2125085120 X-MICROSOFT-CDO-BUSYSTATUS:TENTATIVE X-MICROSOFT-CDO-INTENDEDSTATUS:BUSY X-MICROSOFT-CDO-ALLDAYEVENT:FALSE X-MICROSOFT-CDO-IMPORTANCE:1 X-MICROSOFT-CDO-INSTTYPE:0 X-MICROSOFT-DONOTFORWARDMEETING:FALSE X-MICROSOFT-DISALLOW-COUNTER:FALSE X-MICROSOFT-REQUESTEDATTENDANCEMODE:DEFAULT X-MICROSOFT-ISRESPONSEREQUESTED:FALSE X-MICROSOFT-LOCATIONDISPLAYNAME:https://fsu.zoom.us/j/94273595552 X-MICROSOFT-LOCATIONSOURCE:None X-MICROSOFT-LOCATIONS:[{"DisplayName":"https://fsu.zoom.us/j/94273595552"\, "LocationAnnotation":""\,"LocationUri":""\,"LocationStreet":""\,"LocationC ity":""\,"LocationState":""\,"LocationCountry":""\,"LocationPostalCode":"" \,"LocationFullAddress":""}] BEGIN:VALARM DESCRIPTION:REMINDER TRIGGER;RELATED=START:-PT5M ACTION:DISPLAY END:VALARM END:VEVENT END:VCALENDAR