<html>
<head>
<meta http-equiv="Content-Type" content="text/html; charset=utf-8">
</head>
<body>
<div style="font-family: Tahoma, Geneva, sans-serif; font-size: 12pt; color: rgb(0, 0, 0);" class="elementToProof ContentPasted0">
<span style="font-size: 14pt;"><b><i>"Stoichiometric Model for the Microtubule-mediated dynamics of centrosome and nucleus"</i></b></span>
<div><br class="ContentPasted0">
</div>
<div class="ContentPasted0"><span style="font-size: 14pt;"><b>Yuan-Nan Young</b></span></div>
<div class="ContentPasted0">New Jersey Institute of Technology</div>
<div><br class="ContentPasted0">
</div>
<div class="ContentPasted0">Please feel free to forward/share this invitation with other groups/disciplines that might be interested in this talk/topic.
<b>All are welcome to attend. </b></div>
<div><br class="ContentPasted0">
</div>
<div class="ContentPasted0"><i>Note: Zoom access is for non-departmental participants only. </i></div>
<div class="ContentPasted0"><br>
</div>
<div class="ContentPasted0"><b>https://fsu.zoom.us/j/94273595552 </b></div>
<div class="ContentPasted0">Meeting # <b>942 7359 5552 </b></div>
<div><br class="ContentPasted0">
</div>
<div class="ContentPasted0">🎦 Colloquium recordings will be made available here,
<a href="https://www.sc.fsu.edu/colloquium">https://www.sc.fsu.edu/colloquium</a> </div>
<div><br class="ContentPasted0">
</div>
<div class="ContentPasted0"><b>Wednesday, Nov 1</b>, 2023, Schedule: </div>
<div class="ContentPasted0">* <b>3:00</b> to 3:30 PM Eastern Time (US and Canada)
</div>
<div class="ContentPasted0">☕ <b>Nespresso & Teatime</b> - 417 DSL Commons </div>
<div><br class="ContentPasted0">
</div>
<div class="ContentPasted0">* <b>3:30</b> to 4:30 PM Eastern Time (US and Canada)
</div>
<div class="ContentPasted0">🕟 <b>Colloquium</b> - 499 DSL Seminar Room </div>
<div><br class="ContentPasted0">
</div>
<div class="ContentPasted0"><b>Abstract:</b></div>
<div class="ContentPasted0">The Stoichiometric Model for the interaction of centrosomes with cortically anchored pulling motors, through their associated microtubules (MTs), has been applied to study key steps in the cell division such as spindle positioning
and elongation. In this work we extend the original Stoichiometric Model to incorporate (1) overlap in the cortical motors, and (2) the dependence of velocity in the detachment rate of MTs from the cortical motors. We examine the effects of motor overlap and
velocity-dependent detachment rate on the centrosome dynamics, such as the radial oscillation around the geometric center of the cell, the nonlinear nature (supercritical and subcritical Hopf bifurcation) of such oscillation, and the nonlinear orbital motions
previously found for a centrosome. We explore biologically feasible parameter regimes where these effects may lead to significantly different centrosome/nucleus dynamics. Furthermore, we use this extended Stoichiometric Model to study the migration of a nucleus
being positioned by a centrosome. This is joint work with Reza Farhadifar and Michael Shelley.</div>
<div><br class="ContentPasted0">
</div>
<div class="ContentPasted0">Additional colloquium details can be found here, </div>
<div class="ContentPasted0"><a href="https://www.sc.fsu.edu/news-and-events/colloquium/1760-colloquium-with-yuan-nan-young-2023-11-01">https://www.sc.fsu.edu/news-and-events/colloquium/1760-colloquium-with-yuan-nan-young-2023-11-01</a> </div>
</div>
</body>
</html>