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<div><span style="font-size: 12pt;"><b>"A Machine Learning Algorithm to Accurately and Efficiently Detect DNA Mutations"</b></span>
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<div><span style="font-size: 12pt;"><b>Xian Fan</b></span></div>
<div><b>Department of Computer Science,</b></div>
<div><b>Florida State University </b></div>
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<div><i>NOTE: Please feel free to forward/share this invitation with other groups/disciplines that might be interested in this talk/topic.
<u><b>All are welcome to attend. </b></u></i></div>
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<div><b>https://fsu.zoom.us/j/94273595552 </b></div>
<div>Meeting # <b>942 7359 5552 </b></div>
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<div><b>Apr 13, 2022, Schedule: </b></div>
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<div>* <b>3:30 to 4:30 PM</b> Eastern Time (US and Canada) </div>
<div><b>Colloquium</b> - Attend F2F (in 499 DSL) or Virtually (via Zoom) </div>
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<div><b style="color: inherit; font-family: inherit; font-size: inherit; font-style: inherit; font-variant-ligatures: inherit; font-variant-caps: inherit;">Abstract:</b><br>
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<div>Human DNA is 3 billion bases long. Mutations on the DNA are those nucleotide changes that have a potential to lead to genetic diseases such as cancer. Mutations vary in the bases involved, from a single nucleotide, to small insertions and deletions (<
50 bases), to large structural variations (> 50 bases).<br>
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<div>The advent of the massively parallel sequencing makes it possible to read human DNA by fragments, allowing some clinical applications such as detecting mutations on DNA. However, the data that we obtained from sequencing machines may contain errors which
will lead to false positive and false negative detections. In addition, the amount of data is huge, leading to a “big data” problem. In this talk, I will summarize my past work in developing computational tools to detect mutations, followed by the introduction
of a particular algorithm, called OMIndel, for detecting small insertions and deletions in human DNA.<br>
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